This chapter identifies cases in which the use of hard or soft gelatin capsules may be preferred over tablets. It describes the types of formulations that are used in hard versus soft gelatin capsules. The chapter also describes quality control tests for soft and hard gelatin capsules. Hard gelatin capsules often provide formulation capability for uniquely challenging drug molecules. Most of th…
Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it …